Linked Life Data

9822378

Source:http://linkedlifedata.com/resource/pubmed/id/9822378

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5393
pubmed:dateCreated
1998-12-14
pubmed:databankReference
pubmed:abstractText
Tankyrase, a protein with homology to ankyrins and to the catalytic domain of poly(adenosine diphosphate-ribose) polymerase (PARP), was identified and localized to human telomeres. Tankyrase binds to the telomeric protein TRF1 (telomeric repeat binding factor-1), a negative regulator of telomere length maintenance. Like ankyrins, tankyrase contains 24 ankyrin repeats in a domain responsible for its interaction with TRF1. Recombinant tankyrase was found to have PARP activity in vitro, with both TRF1 and tankyrase functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. ADP-ribosylation of TRF1 diminished its ability to bind to telomeric DNA in vitro, suggesting that telomere function in human cells is regulated by poly(ADP-ribosyl)ation.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
282
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1484-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9822378-Adenosine Diphosphate Ribose, pubmed-meshheading:9822378-Amino Acid Sequence, pubmed-meshheading:9822378-Animals, pubmed-meshheading:9822378-Ankyrins, pubmed-meshheading:9822378-Benzamides, pubmed-meshheading:9822378-Catalytic Domain, pubmed-meshheading:9822378-DNA, pubmed-meshheading:9822378-DNA-Binding Proteins, pubmed-meshheading:9822378-Enzyme Inhibitors, pubmed-meshheading:9822378-Fluorescent Antibody Technique, Indirect, pubmed-meshheading:9822378-Humans, pubmed-meshheading:9822378-Molecular Sequence Data, pubmed-meshheading:9822378-NAD, pubmed-meshheading:9822378-Poly(ADP-ribose) Polymerases, pubmed-meshheading:9822378-Protein Structure, Secondary, pubmed-meshheading:9822378-Recombinant Proteins, pubmed-meshheading:9822378-Repetitive Sequences, Amino Acid, pubmed-meshheading:9822378-Sequence Alignment, pubmed-meshheading:9822378-Sequence Homology, Amino Acid, pubmed-meshheading:9822378-Tankyrases, pubmed-meshheading:9822378-Telomere, pubmed-meshheading:9822378-Telomeric Repeat Binding Protein 1
pubmed:year
1998
pubmed:articleTitle
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.
pubmed:affiliation
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
pubmed:publicationType
Journal Article, Comment, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't