Linked Life Data

9820738

Source:http://linkedlifedata.com/resource/pubmed/id/9820738

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-12-9
pubmed:abstractText
The host-pathogen relationship is the focus of many different studies which use a variety of disease models and different pathogens. Immunological studies in the mouse using the intracellular parasite Leishmania have helped define several aspects of host-pathogen interactions. Resistance to Leishmania is dependent on the development of CD4+ Th1 cells which promote an effective cell mediated immune response. Production of the cytokine IFN-gamma during this immune response activates macrophages enabling them to kill the parasite and control the infection. In contrast, susceptibility to this parasite is characterized by a Th2 response which produces predominantly IL-4. This cytokine promotes high antibody titers directed towards the parasite but does not activate macrophages for parasite killing. This host response results in high parasite numbers and a progressive increase in lesion size. The mouse model of leishmaniasis has been extremely useful in gaining an understanding of the immunological factors important in determining T cell commitment into Th1 or Th2 populations during an in vivo immune response.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
D1171-80
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Host susceptibility factors to cutaneous leishmaniasis.
pubmed:affiliation
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. jonesdou@mail.med. upenn.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review