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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1998-12-7
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pubmed:abstractText |
Src homology-2 domain-containing inositol polyphosphate 5'-phosphatase (SHIP) is a recently identified protein that has been implicated as an important signaling molecule. Although SHIP has been shown to participate in the FcgammaRIIB-mediated inhibitory signal, the functional role of SHIP in activation responses by immunoreceptor tyrosine-based activation motif-bearing receptors such as B cell receptor (BCR) remains unclear. Indeed, it has been proposed that SHIP serves as a linking molecule for the regulation of the extracellular signal-regulated kinase pathway in BCR signaling, because SHIP associates with Shc. We now report that SHIP-deficient DT40 B cells display enhanced Ca2+ mobilization in response to BCR ligation, whereas extracellular signal-regulated kinase activation is unaffected. This Ca2+ enhancement is due to a sustained intracellular Ca2+ increase or to long-lasting Ca2+ oscillations by loss of SHIP, as revealed by single-cell Ca2+ imaging analysis. These results demonstrate the importance of SHIP in B cell activation by the modulation of Ca2+ mobilization.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Fc gamma receptor IIB,
http://linkedlifedata.com/resource/pubmed/chemical/INPPL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ITPR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol 1,4,5-Trisphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol 1,4,5-Trisphosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Monoester Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/antigen T cell receptor, zeta chain
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
161
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5129-32
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9820480-Animals,
pubmed-meshheading:9820480-Antigens, CD,
pubmed-meshheading:9820480-B-Lymphocytes,
pubmed-meshheading:9820480-Calcium,
pubmed-meshheading:9820480-Calcium Channels,
pubmed-meshheading:9820480-Calcium Signaling,
pubmed-meshheading:9820480-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9820480-Cell Line,
pubmed-meshheading:9820480-Chickens,
pubmed-meshheading:9820480-Enzyme Activation,
pubmed-meshheading:9820480-Inositol 1,4,5-Trisphosphate,
pubmed-meshheading:9820480-Inositol 1,4,5-Trisphosphate Receptors,
pubmed-meshheading:9820480-Membrane Proteins,
pubmed-meshheading:9820480-Phosphoric Monoester Hydrolases,
pubmed-meshheading:9820480-Protein Binding,
pubmed-meshheading:9820480-Protein-Tyrosine Kinases,
pubmed-meshheading:9820480-Receptors, Antigen, B-Cell,
pubmed-meshheading:9820480-Receptors, Antigen, T-Cell,
pubmed-meshheading:9820480-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:9820480-Receptors, IgG,
pubmed-meshheading:9820480-Transfection,
pubmed-meshheading:9820480-src Homology Domains
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pubmed:year |
1998
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pubmed:articleTitle |
Role of the inositol phosphatase SHIP in B cell receptor-induced Ca2+ oscillatory response.
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pubmed:affiliation |
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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