Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1998-12-24
pubmed:abstractText
Members of the C/EBP (CCAAT/enhancer binding protein) family of transcription factors play important roles in mediating the acute-phase response (APR), an inflammatory process resulting from infection and/or tissue damage. Among the C/EBP family of proteins, C/EBPbeta and -delta were thought to be the primary mediators of the APR. The function of C/EBPalpha in the APR has not been fully characterized to date. Here, we investigate the role of C/EBPalpha in the APR by using neonatal mice that lack C/EBPalpha expression. Northern blot analysis of acute-phase protein gene expression in neonatal mice treated with purified bacterial lipopolysaccharide or recombinant interleukin 1beta as an inflammation stimulus showed a strong APR in wild-type mice, but a response in C/EBPalpha null animals was completely lacking. The C/EBPalpha knockout and wild-type mice demonstrated elevations in C/EBPbeta and -delta mRNA expression and DNA binding as well as increased DNA binding of NF-kappaB, all of which are known to be important in the APR. Null mice, however, failed to activate STAT3 binding in response to lipopolysaccharide. Our results provide the first evidence that C/EBPalpha is absolutely required for the APR in neonatal mice, is involved in STAT3 regulation, and cannot be compensated for by other C/EBP family members.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-1371993, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-1377908, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-1380488, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-1408789, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-1718961, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-1741402, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-1757124, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-1869549, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-1934061, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-2001421, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-2112087, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-2128877, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-2196441, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-2558052, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-2786140, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-2792758, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-3043186, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-7545365, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-7590248, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-7592638, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-7652557, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-7680115, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-7862113, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-7867060, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-7931061, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-7959007, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8007954, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8127368, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8140422, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8196668, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8234276, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8244962, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8246983, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8321203, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8340393, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8367486, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8385337, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8530402, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8608586, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8611141, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8621420, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8621622, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8628285, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8628296, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8634432, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8657133, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8683129, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8754826, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8939729, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-8997368, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-9002549, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-9163525, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-9169415, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-9223320, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-9287210, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-9343424, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-9372966, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-9505140, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-9614188, http://linkedlifedata.com/resource/pubmed/commentcorrection/9819413-9653078
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7269-77
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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