| pubmed-article:9818790 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9818790 | lifeskim:mentions | umls-concept:C0016720 | lld:lifeskim |
| pubmed-article:9818790 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:9818790 | lifeskim:mentions | umls-concept:C0043474 | lld:lifeskim |
| pubmed-article:9818790 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9818790 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9818790 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9818790 | lifeskim:mentions | umls-concept:C0053664 | lld:lifeskim |
| pubmed-article:9818790 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:9818790 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:9818790 | pubmed:dateCreated | 1999-1-7 | lld:pubmed |
| pubmed-article:9818790 | pubmed:abstractText | Biphalin is a bivalent opioid analogue containing two tyrosine residues. We have examined the effect of biphalin's anti-retroviral potency in vitro using a murine model. Biphalin, in non-cytotoxic concentrations, suppressed in a dose-dependent fashion the replication of Friend leukemia virus (FLV) in Mus dunni cells as determined using a focus forming assay. FLV replication was substantially reduced by biphalin at 10(-4) M concentration. When biphalin was combined with 3'-azido-3'-deoxythymidine (AZT) the two acted synergistically in inhibiting FLV replication compared to either used alone. Using a reverse transcriptase (RT) assay, FLV RT levels also were noted to be reduced in the presence of biphalin. These observations indicate that biphalin possesses anti-retroviral activity in vitro, suggesting that this opioid peptide should be examined further in vivo to determine if it is a candidate for combined therapy with AZT and possibly other drugs for retrovirus infections including the human immunodeficiency virus (HIV). | lld:pubmed |
| pubmed-article:9818790 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9818790 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9818790 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9818790 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9818790 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9818790 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9818790 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9818790 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9818790 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9818790 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9818790 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9818790 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9818790 | pubmed:issn | 0192-0561 | lld:pubmed |
| pubmed-article:9818790 | pubmed:author | pubmed-author:SpecterSS | lld:pubmed |
| pubmed-article:9818790 | pubmed:author | pubmed-author:LipkowskiA... | lld:pubmed |
| pubmed-article:9818790 | pubmed:author | pubmed-author:TangJ LJL | lld:pubmed |
| pubmed-article:9818790 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9818790 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:9818790 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9818790 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9818790 | pubmed:pagination | 457-66 | lld:pubmed |
| pubmed-article:9818790 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9818790 | pubmed:meshHeading | pubmed-meshheading:9818790-... | lld:pubmed |
| pubmed-article:9818790 | pubmed:meshHeading | pubmed-meshheading:9818790-... | lld:pubmed |
| pubmed-article:9818790 | pubmed:meshHeading | pubmed-meshheading:9818790-... | lld:pubmed |
| pubmed-article:9818790 | pubmed:meshHeading | pubmed-meshheading:9818790-... | lld:pubmed |
| pubmed-article:9818790 | pubmed:meshHeading | pubmed-meshheading:9818790-... | lld:pubmed |
| pubmed-article:9818790 | pubmed:meshHeading | pubmed-meshheading:9818790-... | lld:pubmed |
| pubmed-article:9818790 | pubmed:meshHeading | pubmed-meshheading:9818790-... | lld:pubmed |
| pubmed-article:9818790 | pubmed:meshHeading | pubmed-meshheading:9818790-... | lld:pubmed |
| pubmed-article:9818790 | pubmed:meshHeading | pubmed-meshheading:9818790-... | lld:pubmed |
| pubmed-article:9818790 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9818790 | pubmed:articleTitle | Inhibitory effect of biphalin and AZT on murine Friend leukemia virus infection in vitro. | lld:pubmed |
| pubmed-article:9818790 | pubmed:affiliation | Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa 33612, USA. | lld:pubmed |
| pubmed-article:9818790 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9818790 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9818790 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
