|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
1999-1-11
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|
pubmed:abstractText |
Cytokines can be engineered for greater potency in stimulating cellular functions. An obvious test criterion for an improved cytokine is receptor-binding affinity, but this does not always correlate with improved biological response. By combining protein-engineering techniques with studies of receptor trafficking and signaling, it might be possible to identify the ligand receptor-binding properties that should be sought.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1074-5521
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
R257-63
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
|
|
pubmed:year |
1998
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|
pubmed:articleTitle |
Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics.
|
|
pubmed:affiliation |
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA. lauffen@mit.edu
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|
pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|
