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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1998-12-17
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pubmed:abstractText |
Saliva was collected prospectively from patients presenting with suspected dengue infection 4 to 8 days after the onset of symptoms and assayed by a commercial dengue immunoglobulin M (IgM) and IgG capture enzyme-linked immunosorbent assay (ELISA) (PanBio Dengue Duo ELISA). Laboratory diagnosis was based on virus isolation and on hemagglutination inhibition (HAI) assay and an in-house IgM and IgG capture ELISA. With a positive result defined as either salivary IgM or IgG levels above the cutoff value, an overall sensitivity of 92% was obtained for both primary- and secondary-dengue patients (22 of 24), while no patients with non-flavivirus infections (n = 11) and no healthy laboratory donors (n = 17) showed elevation of salivary antidengue antibody (100% specificity). Salivary IgG levels correlated well with serum HAI titer (r = 0.78), and salivary IgG levels could be used to distinguish between primary- and secondary-dengue virus infections.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-1475834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-2495200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-2540664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-2550585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-3341519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-7747294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-8146129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-8355022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-9137865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-9220163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-9237696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-9431954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-9455871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-9574674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817913-9646004
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3737-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9817913-Antibodies, Viral,
pubmed-meshheading:9817913-Dengue,
pubmed-meshheading:9817913-Dengue Virus,
pubmed-meshheading:9817913-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9817913-Humans,
pubmed-meshheading:9817913-Immunoglobulin A, Secretory,
pubmed-meshheading:9817913-Immunoglobulin G,
pubmed-meshheading:9817913-Immunoglobulin M,
pubmed-meshheading:9817913-Prospective Studies,
pubmed-meshheading:9817913-Saliva,
pubmed-meshheading:9817913-Sensitivity and Specificity
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pubmed:year |
1998
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pubmed:articleTitle |
Detection of specific antibodies in saliva during dengue infection.
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pubmed:affiliation |
PanBio Pty Ltd., Windsor, Queensland, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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