Linked Life Data

9817697

Source:http://linkedlifedata.com/resource/pubmed/id/9817697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 1
pubmed:dateCreated
1998-12-18
pubmed:abstractText
We used amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) to document the prevalence of three mutations in the beta chain of the high-affinity IgE receptor (Fcepsilon RI-beta): I181L, V183L, and E237G in a sample of black and white asthmatic and control subjects in South Africa to determine whether these variants contribute to the enhanced IgE responses in these groups and also to determine whether the discrepancy in the prevalence of atopy in these groups could be attributed to these variants, as whites tend to be more atopic than blacks. There was a significant difference in the frequency of I181L between white asthmatics (28%) and white control subjects (3%) (p = 0.00001), and between black control subjects (16%) and white control subjects (p = 0.002); no difference in the frequency of I181L was observed between black asthmatics (22%) and black control subjects (16%). V183L was found in one black asthmatic who was also positive for I181L and E237G. There was a significant difference in the frequency of E237G between black asthmatics (20%) and white asthmatics (12%) (p = 0.05), and between control subjects (20%) and white control subjects (5%) (p = 0.003). E237G was more prevalent in blacks (20%) than in whites (8.5%) (p = 0.001). I181L might predispose to atopy in the white population, but not in the black population. The significantly higher prevalence of E237G in blacks than in whites might explain why blacks tend to have more severe asthma than whites and might offer more insight into the higher asthma mortality rate in the black population as compared with the white population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1073-449X
pubmed:author
pubmed:issnType
Print
pubmed:volume
158
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1487-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9817697-Adolescent, pubmed-meshheading:9817697-Adult, pubmed-meshheading:9817697-African Continental Ancestry Group, pubmed-meshheading:9817697-Asthma, pubmed-meshheading:9817697-Chi-Square Distribution, pubmed-meshheading:9817697-Child, pubmed-meshheading:9817697-European Continental Ancestry Group, pubmed-meshheading:9817697-Exons, pubmed-meshheading:9817697-Female, pubmed-meshheading:9817697-Gene Frequency, pubmed-meshheading:9817697-Glutamic Acid, pubmed-meshheading:9817697-Glycine, pubmed-meshheading:9817697-Humans, pubmed-meshheading:9817697-Hypersensitivity, Immediate, pubmed-meshheading:9817697-Immunoglobulin E, pubmed-meshheading:9817697-Isoleucine, pubmed-meshheading:9817697-Leucine, pubmed-meshheading:9817697-Male, pubmed-meshheading:9817697-Middle Aged, pubmed-meshheading:9817697-Mutation, pubmed-meshheading:9817697-Polymerase Chain Reaction, pubmed-meshheading:9817697-Polymorphism, Genetic, pubmed-meshheading:9817697-Prevalence, pubmed-meshheading:9817697-Receptors, IgE, pubmed-meshheading:9817697-South Africa, pubmed-meshheading:9817697-Valine
pubmed:year
1998
pubmed:articleTitle
Polymorphisms of the beta chain of the high-affinity immunoglobulin E receptor (Fcepsilon RI-beta) in South African black and white asthmatic and nonasthmatic individuals.
pubmed:affiliation
Department of Medicine, University of the Witwatersrand Medical School, Department of Microbiology, University of the Witwatersrand, Johannesburg, South Africa.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't