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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1999-1-20
|
| pubmed:abstractText |
Clinical symptoms and immunological changes associated with HIV-2 infection were studied in a cohort of police officers in Guinea-Bissau. HIV-related symptoms were classified according to the WHO clinical staging system. The inclusion period was from January 1990 to January 1997, and among 2637 subjects included (90.7%M, 9.3%F), the prevalence of HIV-1, HIV-2 and dual reactivity to both HIV-1 and HIV-2 was 0.9%, 9.7% and 0.5%, respectively. Weight loss > 10%, diarrhoea or fever > 1 month, generalized lymphadenopathy and generalized pruritic dermatitis were significantly associated with HIV-2 infection as well as suppression of CD4 cells as compared with HIV-negative controls. Females had significantly higher CD4 cell counts than males, both among HIV-negative and HIV-2-positive asymptomatic individuals. The mortality rates/100 person-years (p.y.) were 0.4 in HIV-negative and 2.6 in HIV-2-positive subjects, giving an age-adjusted mortality rate ratio of 6.6 (95% CI, 4.0-10.9; p < 0.001). The mortality rate among HIV-2-infected individuals varied considerably in different stages of the WHO clinical staging system; 1.7 and 8.0/100 p.y. in stage 1 and 3, respectively.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0036-5548
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
323-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9817509-Adolescent,
pubmed-meshheading:9817509-Adult,
pubmed-meshheading:9817509-CD4 Lymphocyte Count,
pubmed-meshheading:9817509-CD4-CD8 Ratio,
pubmed-meshheading:9817509-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9817509-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9817509-Cohort Studies,
pubmed-meshheading:9817509-Female,
pubmed-meshheading:9817509-Guinea-Bissau,
pubmed-meshheading:9817509-HIV Infections,
pubmed-meshheading:9817509-HIV Seronegativity,
pubmed-meshheading:9817509-HIV Seroprevalence,
pubmed-meshheading:9817509-HIV-1,
pubmed-meshheading:9817509-HIV-2,
pubmed-meshheading:9817509-Humans,
pubmed-meshheading:9817509-Male,
pubmed-meshheading:9817509-Middle Aged,
pubmed-meshheading:9817509-Police,
pubmed-meshheading:9817509-Prospective Studies,
pubmed-meshheading:9817509-Sex Factors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Clinical features, immunological changes and mortality in a cohort of HIV-2-infected individuals in Bissau, Guinea-Bissau.
|
| pubmed:affiliation |
National Public Health Laboratory, Bissau, Guinea-Bissau, Guinea-Bissau.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|