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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6 Pt 1
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pubmed:dateCreated |
1998-12-23
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pubmed:abstractText |
Approximately 15% of patients with ureteropelvic junction obstruction have endopyelotomy failure and require an additional surgical procedure to remove the obstruction. Transforming growth factor-beta (TGF-beta), a cytokine which stimulates mesenchymal cell proliferation and extracellular matrix deposition, increases in the renal pelvis in response to obstruction. However, TGF-beta also is implicated in smooth muscle regeneration and wound healing. To understand the pathophysiology of ureteropelvic junction obstruction and determine why endopyelotomy fails in some obstructed ureteropelvic junctions, TGF-beta expression in obstructed and normal ureteropelvic junction segments was compared.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-5347
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
160
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1991-4
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9817307-Female,
pubmed-meshheading:9817307-Humans,
pubmed-meshheading:9817307-Kidney Pelvis,
pubmed-meshheading:9817307-Male,
pubmed-meshheading:9817307-Transforming Growth Factor beta,
pubmed-meshheading:9817307-Treatment Failure,
pubmed-meshheading:9817307-Ureter,
pubmed-meshheading:9817307-Ureteral Obstruction
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pubmed:year |
1998
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pubmed:articleTitle |
Endopyelotomy failure is associated with reduced transforming growth factor-beta.
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pubmed:affiliation |
Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York, USA.
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pubmed:publicationType |
Journal Article
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