Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1998-11-18
pubmed:abstractText
We have previously suggested that colorectal liver metastases might produce 'toxins' that reduce both quality of life (QoL) and survival. In this study we assessed whether QoL in patients with such metastases was related to immune activation, as determined by increased serum levels of interleukin 6 (IL6), soluble tumour necrosis factor receptor 1 (sTNFr1), soluble interleukin 2 receptor alpha (sIL2r alpha) or the interferon-gamma marker neopterin. Serum IL6, sTNFr1, sIL2r alpha, neopterin, alkaline phosphatase and carcinoembryonic antigen levels, liver metastasis volume, and QoL (Hospital Anxiety and Depression [HAD] scale, Rotterdam Symptom Checklist [RSC], and Sickness Impact Profile [SIP]) were measured in 43 patients. There were significant positive correlations between serum sIL2r alpha and HAD depression score (r = 0.66, P = 0.0001), RSC physical symptom score (r = 0.46, P < 0.01), and SIP score (r = 0.47, P = 0.009). Multiple regression analysis suggested that serum sIL2r alpha level was a significant independent predictor of HAD depression score. Although survival was shorter (logrank test P < 0.05) where sIL2r alpha, sTNFr1 and IL6 levels were higher, the ability of sIL2r alpha to predict HAD depression score was independent of survival.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-1820762, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-1825941, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-2257209, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-3487366, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-3872925, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-5486604, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-6880820, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-7278416, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-7518332, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-7525035, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-7622184, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-7669825, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-7710957, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-7907273, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-7951851, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-8074478, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-8142118, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-8145906, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-8146526, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-831755, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-8443808, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-8483498, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-8558193, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-8608841, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-8614003, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-9099972, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-9164214, http://linkedlifedata.com/resource/pubmed/commentcorrection/9816354-9361594
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0141-0768
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
408-13
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Relation between depression and circulating immune products in patients with advanced colorectal cancer.
pubmed:affiliation
Department of Gastrointestinal Surgery, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK. t.allen-mersh@cxwmx.ac.uk
pubmed:publicationType
Journal Article