Linked Life Data

9815659

Source:http://linkedlifedata.com/resource/pubmed/id/9815659

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12 Pt 2
pubmed:dateCreated
1999-3-3
pubmed:abstractText
Endogenous cytokines are aberrantly produced in many cancers and serve as autocrine growth factors or indicators of immune response to the tumors. Hence, cytokine deregulation is likely to participate in the development or evolution of the malignant process. Over the last few years, we have performed a series of studies, with the objective of measuring cytokine levels in tumors and correlating endogenous levels with phenotypic manifestations of cancer and with prognosis. Here, we present our analysis of serum interleukin 6 (IL-6) levels in lymphomas. We demonstrate that IL-6 levels are elevated in both relapsed and newly diagnosed Hodgkin's and non-Hodgkin's lymphoma and that these levels correlate with established prognostic features. Furthermore, in diffuse large cell lymphoma, IL-6 is an independent prognostic variable for both complete remission and failure-free survival. The molecular mechanisms underlying cytokine deregulation are now being investigated, with preliminary data from our laboratory suggesting heterogeneous genetic driving forces. In some cases, oncogene aberrations, particularly in the RAS system, may be responsible.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2581-4
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Cytokine deregulation in hematological malignancies: clinical and biological implications.
pubmed:affiliation
Departments of Hematology and Bioimmunotherapy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
pubmed:publicationType
Journal Article, Review