Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1999-1-14
pubmed:abstractText
The pleiotrophic but overlapping functions of the cytokine family that includes interleukin (IL)-6, IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin 1 are mediated by the cytokine receptor subunit gp130 as the common signal transducer. Although mice lacking individual members of this family display only mild phenotypes, animals lacking gp130 are not viable. To assess the collective role of this cytokine family, we inducibly inactivated gp130 via Cre-loxP-mediated recombination in vivo. Such conditional mutant mice exhibited neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects, demonstrating the widespread importance of gp130-dependent cytokines.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-1522892, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-1631092, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-2679136, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-2798426, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-3034596, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-3258006, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-6193754, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-7501019, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-7517363, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-7585948, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-7632937, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-7660125, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-7768607, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-7789261, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-7895162, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-7931061, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8127368, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8131749, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8160012, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8293462, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8361533, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8375338, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8389912, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8418208, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8456301, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8497320, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8499074, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8513499, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8551238, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8552649, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8634432, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8666893, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8698848, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8793295, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8822921, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8910279, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-8939573, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9063729, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9075932, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9143707, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9169772, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9198001, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9207450, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9310465, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9314070, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9348227, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9419213, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9425117, http://linkedlifedata.com/resource/pubmed/commentcorrection/9815272-9500603
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
188
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1955-65
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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