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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1999-1-7
|
| pubmed:abstractText |
Herpes simplex virus (HSV) infection is common in persons coinfected with human immunodeficiency virus (HIV). In a prospective study, daily viral cultures of the mouth, genitals, and rectum were collected from 68 HIV-positive and 13 HIV-negative men who have sex with men. Subjects completed a median of 57 days of follow-up. Anogenital HSV-2 cultures were positive on 405 (9.7%) of 4167 days for HIV-positive men and on 24 (3.1%) of 766 days for HIV-negative men. Most reactivations were perirectal and subclinical. Risk factors for increased HSV-2 shedding among HIV-positive men were low CD4 cell count (odds ratio, 2.5; 95% confidence interval, 1.2-5.4) and antibodies to both HSV-1 and HSV-2 versus HSV-2 only (odds ratio, 1.9; 95% confidence interval, 1.0-3.7). Three isolates obtained from 3 separate subjects were resistant to acyclovir. Thus, subclinical HSV-2 reactivation is an important opportunistic infection in persons with HIV infection. Further studies are necessaryto determine the impact of subclinical HSV-2 reactivation on the natural history of HIV infection.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
178
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1616-22
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9815213-Acyclovir,
pubmed-meshheading:9815213-Adult,
pubmed-meshheading:9815213-Aged,
pubmed-meshheading:9815213-Antibodies, Viral,
pubmed-meshheading:9815213-Antiviral Agents,
pubmed-meshheading:9815213-CD4 Lymphocyte Count,
pubmed-meshheading:9815213-Confidence Intervals,
pubmed-meshheading:9815213-Follow-Up Studies,
pubmed-meshheading:9815213-Genitalia, Male,
pubmed-meshheading:9815213-HIV Infections,
pubmed-meshheading:9815213-HIV Seronegativity,
pubmed-meshheading:9815213-Herpes Genitalis,
pubmed-meshheading:9815213-Herpesvirus 1, Human,
pubmed-meshheading:9815213-Herpesvirus 2, Human,
pubmed-meshheading:9815213-Homosexuality, Male,
pubmed-meshheading:9815213-Humans,
pubmed-meshheading:9815213-Male,
pubmed-meshheading:9815213-Middle Aged,
pubmed-meshheading:9815213-Mouth,
pubmed-meshheading:9815213-Odds Ratio,
pubmed-meshheading:9815213-Rectum,
pubmed-meshheading:9815213-Recurrence,
pubmed-meshheading:9815213-Risk Factors,
pubmed-meshheading:9815213-Virus Activation,
pubmed-meshheading:9815213-Virus Shedding
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Frequency of symptomatic and asymptomatic herpes simplex virus type 2 reactivations among human immunodeficiency virus-infected men.
|
| pubmed:affiliation |
Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. schac008@Linti.med.umn.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|