Linked Life Data

9814714

Source:http://linkedlifedata.com/resource/pubmed/id/9814714

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-11-20
pubmed:abstractText
Reported residential fungal contamination has been associated consistently with increased symptoms among occupants; however, an objective measure of a health effect is lacking, and a pathophysiologic mechanism has not been established. Our objective was to determine if exposure to indoor fungal contamination influenced T-cell differentiation. In this study, we contrasted lymphocyte populations, measured by flow cytometry, between a group of children who lived in homes with considerable fungal contamination (n = 39) and a group in less-contaminated homes (n = 20). Indicators of fungal biomass were viable fungi in house dust and air ergosterol in the child's bedroom. Living in a more-contaminated home versus a less-contaminated home was associated with a larger number of CD3+ T cells expressing CD45RO (1.5 x 10(9)/I versus 1.1 x 10(9)/I, respectively; p = .05, two-tailed t testing) and a reduced CD4/CD8 ratio (1.6 versus 1.8, respectively; p = .04). The differences persisted over a 12-mo period, and they were not explained by the child's age or total serum IgE, dust mite antigens, and the presence of furry or feathered pets or a humidifier. The results suggest that residential fungal contamination leads to chronic stimulation of children's lymphocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-9896
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
190-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Influence of residential fungal contamination on peripheral blood lymphocyte populations in children.
pubmed:affiliation
Health Effects Research Section, Environmental and Occupational Toxicology, Health Canada, Ottawa.
pubmed:publicationType
Journal Article