|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0026609,
umls-concept:C0026845,
umls-concept:C0337051,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0445254,
umls-concept:C0449560,
umls-concept:C0812380,
umls-concept:C0813971,
umls-concept:C1509144,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1704788,
umls-concept:C1705691,
umls-concept:C1707511
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1998-12-7
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Motor function depends on the formation of selective connections between sensory and motor neurons and their muscle targets. The molecular basis of the specificity inherent in this sensory-motor circuit remains unclear. We show that motor neuron pools and subsets of muscle sensory afferents can be defined by the expression of ETS genes, notably PEA3 and ER81. There is a matching in PEA3 and ER81 expression by functionally interconnected sensory and motor neurons. ETS gene expression by motor and sensory neurons fails to occur after limb ablation, suggesting that their expression is coordinated by signals from the periphery. ETS genes may therefore participate in the development of selective sensory-motor circuits in the spinal cord.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ETS translocation variant 6 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, trkA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, trkC,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nerve Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/transcription factor PEA3
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0092-8674
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
30
|
|
pubmed:volume |
95
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
393-407
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:9814709-Animals,
pubmed-meshheading:9814709-Cell Movement,
pubmed-meshheading:9814709-Chick Embryo,
pubmed-meshheading:9814709-DNA-Binding Proteins,
pubmed-meshheading:9814709-Extremities,
pubmed-meshheading:9814709-Ganglia, Spinal,
pubmed-meshheading:9814709-Gene Expression Regulation, Developmental,
pubmed-meshheading:9814709-Homeodomain Proteins,
pubmed-meshheading:9814709-Mesoderm,
pubmed-meshheading:9814709-Molecular Sequence Data,
pubmed-meshheading:9814709-Motor Neurons,
pubmed-meshheading:9814709-Muscle, Skeletal,
pubmed-meshheading:9814709-Neurons, Afferent,
pubmed-meshheading:9814709-Proto-Oncogene Proteins,
pubmed-meshheading:9814709-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:9814709-Receptor, trkA,
pubmed-meshheading:9814709-Receptor, trkC,
pubmed-meshheading:9814709-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:9814709-Receptors, Nerve Growth Factor,
pubmed-meshheading:9814709-Repressor Proteins,
pubmed-meshheading:9814709-Signal Transduction,
pubmed-meshheading:9814709-Spinal Cord,
pubmed-meshheading:9814709-Transcription Factors
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression.
|
|
pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
