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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5392
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pubmed:dateCreated |
1998-12-1
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pubmed:abstractText |
The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-alpha converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-alpha (TNFalpha) is released. Analyses of cells lacking this metalloproteinase-disintegrin revealed an expanded role for TACE in the processing of other cell surface proteins, including a TNF receptor, the L-selectin adhesion molecule, and transforming growth factor-alpha (TGFalpha). The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
pubmed-author:BlackR ARA,
pubmed-author:BoyceR WRW,
pubmed-author:CastnerB JBJ,
pubmed-author:CerrettiD PDP,
pubmed-author:FitznerJ NJN,
pubmed-author:JohnsonR SRS,
pubmed-author:KozloskyC JCJ,
pubmed-author:LeeD CDC,
pubmed-author:MarchC JCJ,
pubmed-author:NelsonNN,
pubmed-author:PaxtonR JRJ,
pubmed-author:PeschonJ JJJ,
pubmed-author:RauchC TCT,
pubmed-author:ReddyPP,
pubmed-author:RussellW EWE,
pubmed-author:SlackJ LJL,
pubmed-author:StockingK LKL,
pubmed-author:SunnarborgS WSW,
pubmed-author:WolfsonM FMF
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
282
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1281-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9812885-ADAM Proteins,
pubmed-meshheading:9812885-Amino Acid Sequence,
pubmed-meshheading:9812885-Animals,
pubmed-meshheading:9812885-Catalytic Domain,
pubmed-meshheading:9812885-Cell Membrane,
pubmed-meshheading:9812885-Cells, Cultured,
pubmed-meshheading:9812885-Crosses, Genetic,
pubmed-meshheading:9812885-Embryonic and Fetal Development,
pubmed-meshheading:9812885-L-Selectin,
pubmed-meshheading:9812885-Ligands,
pubmed-meshheading:9812885-Membrane Proteins,
pubmed-meshheading:9812885-Metalloendopeptidases,
pubmed-meshheading:9812885-Mice,
pubmed-meshheading:9812885-Mice, Inbred C57BL,
pubmed-meshheading:9812885-Molecular Sequence Data,
pubmed-meshheading:9812885-Mutation,
pubmed-meshheading:9812885-Phenotype,
pubmed-meshheading:9812885-Protein Processing, Post-Translational,
pubmed-meshheading:9812885-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:9812885-Transforming Growth Factor alpha,
pubmed-meshheading:9812885-Tumor Necrosis Factor-alpha
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pubmed:year |
1998
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pubmed:articleTitle |
An essential role for ectodomain shedding in mammalian development.
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pubmed:affiliation |
Immunex Corporation, Seattle, WA 98101, USA. peschon@immunex.com
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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