Linked Life Data

9812846

Source:http://linkedlifedata.com/resource/pubmed/id/9812846

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-1-5
pubmed:abstractText
Using in vivo microdialysis coupled with HPLC-fluorescent detection chemical analysis method, levels of excitatory amino acid were monitored in the caudate nucleus of rhesus monkeys (Macaca mulatta) during performance of a delayed go/no-go task in which movement or no-movement responses were executed depending on the position of a cue light. It was found that the levels of glutamate and aspartate in caudate microdialysates decreased by (31.68 +/- 3.85)% (n = 10, t9 = 6.51, P < 0.001) and (26.25 +/- 5.95)% (n = 10, t9 = 3.39, P < 0.01) respectively during the delayed go/no-go task performance as compared to their basal levels before the task performance. Glutamine and asparagine levels were also found decreased significantly (P < 0.05). In contrast, no such decreases were seen when the monkey performing a non-delayed go/no-go task or performing the task composed of delayed go-trials only. The results suggest that the excitatory amino acid transmission in the caudate nucleus may be involved in the delayed go/no-go task performance, and thereby provide a direct evidence for the modulation of motor working memory by glutamatergic transmission in caudate nucleus.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0371-0874
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
128-34
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
[A microdialysis study of excitatory amino acid levels of the monkeys' caudate nucleus during the delayed go/no-go task].
pubmed:affiliation
Shanghai Institute of Physiology, Chinese Academy of Sciences.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't