| pubmed-article:9811794 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9811794 | lifeskim:mentions | umls-concept:C0034865 | lld:lifeskim |
| pubmed-article:9811794 | lifeskim:mentions | umls-concept:C0319544 | lld:lifeskim |
| pubmed-article:9811794 | lifeskim:mentions | umls-concept:C0162741 | lld:lifeskim |
| pubmed-article:9811794 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:9811794 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:9811794 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:9811794 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:9811794 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:9811794 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9811794 | pubmed:dateCreated | 1999-2-4 | lld:pubmed |
| pubmed-article:9811794 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9811794 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9811794 | pubmed:abstractText | Pathogen resistance (R) genes of the NBS-LRR class (for nucleotide binding site and leucine-rich repeat) are found in many plant species and confer resistance to a diverse spectrum of pathogens. Little is known about the mechanisms that drive NBS-LRR gene evolution in the host-pathogen arms race. We cloned the RPP8 gene (for resistance to Peronospora parasitica) and compared the structure of alleles at this locus in resistant Landsberg erecta (Ler-0) and susceptible Columbia (Col-0) accessions. RPP8-Ler encodes an NBS-LRR protein with a putative N-terminal leucine zipper and is more closely related to previously cloned R genes that confer resistance to bacterial pathogens than it is to other known RPP genes. The RPP8 haplotype in Ler-0 contains the functional RPP8-Ler gene and a nonfunctional homolog, RPH8A. In contrast, the rpp8 locus in Col-0 contains a single chimeric gene, which was likely derived from unequal crossing over between RPP8-Ler and RPH8A ancestors within a Ler-like haplotype. Sequence divergence among RPP8 family members has been accelerated by positive selection on the putative ligand binding region in the LRRs. These observations indicate that NBS-LRR molecular evolution is driven by the same mechanisms that promote rapid sequence diversification among other genes involved in non-self-recognition. | lld:pubmed |
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| pubmed-article:9811794 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9811794 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9811794 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9811794 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9811794 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9811794 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9811794 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9811794 | pubmed:issn | 1040-4651 | lld:pubmed |
| pubmed-article:9811794 | pubmed:author | pubmed-author:GoffSS | lld:pubmed |
| pubmed-article:9811794 | pubmed:author | pubmed-author:McDowellJ MJM | lld:pubmed |
| pubmed-article:9811794 | pubmed:author | pubmed-author:LongT ATA | lld:pubmed |
| pubmed-article:9811794 | pubmed:author | pubmed-author:DanglJ LJL | lld:pubmed |
| pubmed-article:9811794 | pubmed:author | pubmed-author:AartsM GMG | lld:pubmed |
| pubmed-article:9811794 | pubmed:author | pubmed-author:HolubE BEB | lld:pubmed |
| pubmed-article:9811794 | pubmed:author | pubmed-author:DhandaydhamMM | lld:pubmed |
| pubmed-article:9811794 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9811794 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:9811794 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9811794 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9811794 | pubmed:pagination | 1861-74 | lld:pubmed |
| pubmed-article:9811794 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:9811794 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9811794 | pubmed:articleTitle | Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resistance at the RPP8 locus of Arabidopsis. | lld:pubmed |
| pubmed-article:9811794 | pubmed:affiliation | Department of Biology, C.B. 3280 Coker Hall, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA. | lld:pubmed |
| pubmed-article:9811794 | pubmed:publicationType | Journal Article | lld:pubmed |
