|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1999-2-4
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Pathogen resistance (R) genes of the NBS-LRR class (for nucleotide binding site and leucine-rich repeat) are found in many plant species and confer resistance to a diverse spectrum of pathogens. Little is known about the mechanisms that drive NBS-LRR gene evolution in the host-pathogen arms race. We cloned the RPP8 gene (for resistance to Peronospora parasitica) and compared the structure of alleles at this locus in resistant Landsberg erecta (Ler-0) and susceptible Columbia (Col-0) accessions. RPP8-Ler encodes an NBS-LRR protein with a putative N-terminal leucine zipper and is more closely related to previously cloned R genes that confer resistance to bacterial pathogens than it is to other known RPP genes. The RPP8 haplotype in Ler-0 contains the functional RPP8-Ler gene and a nonfunctional homolog, RPH8A. In contrast, the rpp8 locus in Col-0 contains a single chimeric gene, which was likely derived from unequal crossing over between RPP8-Ler and RPH8A ancestors within a Ler-like haplotype. Sequence divergence among RPP8 family members has been accelerated by positive selection on the putative ligand binding region in the LRRs. These observations indicate that NBS-LRR molecular evolution is driven by the same mechanisms that promote rapid sequence diversification among other genes involved in non-self-recognition.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-1346933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-1463855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-15012524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-15012525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-1799694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-2088175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-2152169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-2231712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-7549479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-7549480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-7556057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-7583641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-7638602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-7700152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-7827490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-7859277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-7902614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-7923358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-7923359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-8022769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-8091210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-8264799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-8525370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-8600539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-8608599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-8676743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-8689679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-8914325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-8986840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9090881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9144966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9212464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9286106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9297968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9413991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9465073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9526500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9530866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9539444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9596635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9707643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9811794-9811793
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1040-4651
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1861-74
|
|
pubmed:dateRevised |
2010-9-13
|
|
pubmed:meshHeading |
pubmed-meshheading:9811794-Alleles,
pubmed-meshheading:9811794-Amino Acid Sequence,
pubmed-meshheading:9811794-Arabidopsis,
pubmed-meshheading:9811794-Base Sequence,
pubmed-meshheading:9811794-Chromosome Mapping,
pubmed-meshheading:9811794-DNA, Plant,
pubmed-meshheading:9811794-Evolution, Molecular,
pubmed-meshheading:9811794-Genes, Plant,
pubmed-meshheading:9811794-Genetic Complementation Test,
pubmed-meshheading:9811794-Molecular Sequence Data,
pubmed-meshheading:9811794-Mutation,
pubmed-meshheading:9811794-Oomycetes,
pubmed-meshheading:9811794-Phenotype,
pubmed-meshheading:9811794-Plant Diseases,
pubmed-meshheading:9811794-Plant Proteins,
pubmed-meshheading:9811794-Plants, Genetically Modified,
pubmed-meshheading:9811794-Recombination, Genetic,
pubmed-meshheading:9811794-Selection, Genetic,
pubmed-meshheading:9811794-Sequence Homology, Amino Acid
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resistance at the RPP8 locus of Arabidopsis.
|
|
pubmed:affiliation |
Department of Biology, C.B. 3280 Coker Hall, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA.
|
|
pubmed:publicationType |
Journal Article
|
