Linked Life Data

9811224

Source:http://linkedlifedata.com/resource/pubmed/id/9811224

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-1-7
pubmed:abstractText
Osteoclasts and odontoclasts are known to increase their nuclear number by fusion of mononuclear precursors. However, the pattern of fusion remains morphologically unclear. One lower right deciduous canine of an 8-year-old male was investigated. Tartrate-resistant acid phosphatase activity (TRAP) positive cells on the resorbing surface of the tooth were serially sectioned into 0.5 microm-thick semithin sections. The sections were photographed, and cells possessing a light microscopic brush border facing a resorptive lacuna were identified as odontoclasts. Fourteen odontoclasts appearing as a continuous figure of cellular membrane between cells on one section were three-dimensionally reconstructed using NIKON COSMOZONE 2SA. A criterion for fusion was established in this study, requiring that there must be two or more nucleated cells which contacted each other at one site only in the three-dimensional reconstruction. Among 14 reconstructed cells, 10 odontoclasts satisfied the criterion for fusion. The observations of the three-dimensional structures of these odontoclasts showed that mononuclear and multinucleated odontoclasts participated in fusion. Cell fusion occurred between resorbing odontoclasts and cells not forming lacunae, and between resorbing odontoclasts. A case of odontoclastic fusion among three cells was also observed. The results establish that fusion resulting in multinucleation occurred among various odontoclasts with different numbers of nuclei including mononuclear odontoclasts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0003-276X
pubmed:author
pubmed:issnType
Print
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
462-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Increase in odontoclast nuclei number by cell fusion: a three-dimensional reconstruction of cell fusion of human odontoclasts.
pubmed:affiliation
Department of Oral Anatomy II, Hokkaido University School of Dentistry, Sapporo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't