Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1998-12-21
|
| pubmed:abstractText |
The presence of circulating "flower cells" and a low prevalence of antibody to Tax regulatory protein of human T-lymphotropic virus type I (HTLV-I) are characteristics of adult T-cell leukemia (ATL). To examine the predictability of levels of HTLV-I antibodies and of flower cell-like abnormal lymphocytes (Ably) for the risk of ATL among asymptomatic HTLV-I carriers, we prospectively evaluated the levels of viral markers of five HTLV-I carriers who developed ATL and 38 age-, sex-, and screen-matched HTLV-I-positive controls in the Miyazaki Cohort Study. After accounting for matching factors, Ably level was slightly, but not significantly, higher among cases than among controls (P =.13). Anti-HTLV-I (odds ratio [OR] = 1.6 per twofold dilution; 95% confidence interval [CI] 0.94, 3.8) was associated with ATL diagnosis, but antibody to Tax regulatory protein (anti-Tax) was not (OR = 0.78; 95% CI 0.26, 1.7). Anti-Tax level was low for all ATL cases for up to 10 years preceding their diagnosis, independent of the level of anti-HTLV-I titer. HTLV-I carriers with a higher anti-HTLV-I titer and a lower anti-Tax reactivity may be at greatest risk of ATL.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
92
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3557-61
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9808547-Adult,
pubmed-meshheading:9808547-Age of Onset,
pubmed-meshheading:9808547-Aged,
pubmed-meshheading:9808547-Aged, 80 and over,
pubmed-meshheading:9808547-Carrier State,
pubmed-meshheading:9808547-Cohort Studies,
pubmed-meshheading:9808547-Female,
pubmed-meshheading:9808547-Gene Products, tax,
pubmed-meshheading:9808547-HTLV-I Antibodies,
pubmed-meshheading:9808547-HTLV-I Infections,
pubmed-meshheading:9808547-Human T-lymphotropic virus 1,
pubmed-meshheading:9808547-Humans,
pubmed-meshheading:9808547-Japan,
pubmed-meshheading:9808547-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:9808547-Male,
pubmed-meshheading:9808547-Middle Aged,
pubmed-meshheading:9808547-Neoplastic Stem Cells,
pubmed-meshheading:9808547-Prospective Studies,
pubmed-meshheading:9808547-Risk Factors,
pubmed-meshheading:9808547-Smoking,
pubmed-meshheading:9808547-T-Lymphocytes,
pubmed-meshheading:9808547-Tumor Markers, Biological
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Risk factors for adult T-cell leukemia among carriers of human T-lymphotropic virus type I.
|
| pubmed:affiliation |
Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA, USA. mh280i@nih.gov
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|