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rdf:type |
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lifeskim:mentions |
umls-concept:C0009491,
umls-concept:C0030956,
umls-concept:C0042196,
umls-concept:C0205171,
umls-concept:C0205263,
umls-concept:C0205369,
umls-concept:C0205373,
umls-concept:C0439661,
umls-concept:C0456387,
umls-concept:C1441547,
umls-concept:C1704410,
umls-concept:C1883254
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pubmed:issue |
8
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pubmed:dateCreated |
1998-11-25
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pubmed:abstractText |
Because T cell receptor-MHC class I/self-peptide interactions regulate T-cell development, the presence of MHC allopeptides in the thymus may influence T-cell tolerance to alloantigens. This hypothesis is supported by our most recent finding that intrathymic (IT) inoculation of nonimmunogenic synthetic peptides derived from "WAG" RT1.A induces tolerance to cardiac allografts in the Wistar-Furth (WF)-to-ACI model. To evaluate whether in vivo immunogenicity of MHC peptides is relevant to tolerance induction and to examine the effect of peptide specificity, we compared the effects on graft survival of well-defined, strain-specific immunogenic WF MHC class I peptides (RT1.AU) with closely related but non-strain-specific class I peptides derived from WAG (RT1U).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1059-66
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9808492-Animals,
pubmed-meshheading:9808492-Cytokines,
pubmed-meshheading:9808492-Cytotoxicity, Immunologic,
pubmed-meshheading:9808492-Graft Survival,
pubmed-meshheading:9808492-Heart Transplantation,
pubmed-meshheading:9808492-Histocompatibility Antigens,
pubmed-meshheading:9808492-Immune Tolerance,
pubmed-meshheading:9808492-Injections,
pubmed-meshheading:9808492-Islets of Langerhans Transplantation,
pubmed-meshheading:9808492-Isoantigens,
pubmed-meshheading:9808492-Lymphocytes,
pubmed-meshheading:9808492-Peptide Fragments,
pubmed-meshheading:9808492-Rats,
pubmed-meshheading:9808492-Rats, Inbred ACI,
pubmed-meshheading:9808492-Rats, Inbred Strains,
pubmed-meshheading:9808492-Rats, Inbred WF,
pubmed-meshheading:9808492-T-Lymphocytes,
pubmed-meshheading:9808492-Thymus Gland
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pubmed:year |
1998
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pubmed:articleTitle |
Comparative studies of specific acquired systemic tolerance induced by intrathymic inoculation of a single synthetic Wistar-Furth (RT1U) allo-MHC class I (RT1.AU) peptide or WAG (RT1U)-derived class I peptide.
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pubmed:affiliation |
Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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