Linked Life Data

9808459

Source:http://linkedlifedata.com/resource/pubmed/id/9808459

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-12-4
pubmed:databankReference
pubmed:abstractText
Group I metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins. Here, we present evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R). A novel proline-rich "Homer ligand" (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate as a complex with Homer from brain. Expression of the IEG form of Homer, which lacks the ability to cross-link, modulates mGluR-induced intracellular calcium release. These studies identify a novel mechanism in calcium signaling and provide evidence that an IEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Dynamins, http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases, http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Homer protein, http://linkedlifedata.com/resource/pubmed/chemical/Inositol 1,4,5-Trisphosphate..., http://linkedlifedata.com/resource/pubmed/chemical/Ligands, http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides, http://linkedlifedata.com/resource/pubmed/chemical/Proline, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
717-26
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9808459-Amino Acid Sequence, pubmed-meshheading:9808459-Animals, pubmed-meshheading:9808459-Calcium, pubmed-meshheading:9808459-Calcium Channels, pubmed-meshheading:9808459-Carrier Proteins, pubmed-meshheading:9808459-Dynamins, pubmed-meshheading:9808459-GTP Phosphohydrolases, pubmed-meshheading:9808459-Gene Expression, pubmed-meshheading:9808459-Genes, Immediate-Early, pubmed-meshheading:9808459-Glutamic Acid, pubmed-meshheading:9808459-Inositol 1,4,5-Trisphosphate Receptors, pubmed-meshheading:9808459-Intracellular Membranes, pubmed-meshheading:9808459-Ligands, pubmed-meshheading:9808459-Molecular Sequence Data, pubmed-meshheading:9808459-Neuropeptides, pubmed-meshheading:9808459-Proline, pubmed-meshheading:9808459-Rats, pubmed-meshheading:9808459-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:9808459-Receptors, Metabotropic Glutamate, pubmed-meshheading:9808459-Time Factors
pubmed:year
1998
pubmed:articleTitle
Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.
pubmed:affiliation
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't