| pubmed-article:9808174 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9808174 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9808174 | lifeskim:mentions | umls-concept:C0021761 | lld:lifeskim |
| pubmed-article:9808174 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9808174 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:9808174 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:9808174 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:9808174 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:9808174 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:9808174 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:9808174 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:9808174 | pubmed:dateCreated | 1998-12-15 | lld:pubmed |
| pubmed-article:9808174 | pubmed:abstractText | This study examines the influence of IL-7 on post-thymic CD4+ T cells using cord blood as a model system. Survival of naive cord blood T cells in the presence of IL-7 alone was significantly prolonged by up-regulating bcl-2, thereby preventing apoptosis while maintaining maximal cell viability. Cultures without IL-7 showed high rates of apoptosis resulting in 50% cell death by day 5 of culture. Upon phorbol 12-myristate 13-acetate + ionomycin stimulation, accumulation of cytoplasmic IL-2 was similar to that observed in freshly isolated cells, but no IL-4- or IFN-gamma-positive cells were detected. IL-7 maintained the naive T cells in a quiescent state expressing the CD45RA antigen. A significant finding was the loss of CD38 antigen expression on the naive cord blood T cells to levels similar to that observed on adult naive T cells. In contrast to the reduced proliferative response of fresh cord blood T cells to anti-CD2 + CD28 stimulation, the proliferative response of IL-7-treated cells was similar to that of adult naive T cells. This study shows that as well as maintaining the naive T cell pool by enhancing cell survival and up-regulating bcl-2 expression, IL-7 also functions as a maturation factor for post-thymic naive T cells. | lld:pubmed |
| pubmed-article:9808174 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9808174 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9808174 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9808174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9808174 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9808174 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9808174 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:9808174 | pubmed:author | pubmed-author:ReenD JDJ | lld:pubmed |
| pubmed-article:9808174 | pubmed:author | pubmed-author:HassalHH | lld:pubmed |
| pubmed-article:9808174 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9808174 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:9808174 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9808174 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9808174 | pubmed:pagination | 3057-65 | lld:pubmed |
| pubmed-article:9808174 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:9808174 | pubmed:meshHeading | pubmed-meshheading:9808174-... | lld:pubmed |
| pubmed-article:9808174 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9808174 | pubmed:articleTitle | IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells. | lld:pubmed |
| pubmed-article:9808174 | pubmed:affiliation | Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland. jaythoon@crumlin.ucd.ie | lld:pubmed |
| pubmed-article:9808174 | pubmed:publicationType | Journal Article | lld:pubmed |
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