9808078

Source:http://linkedlifedata.com/resource/pubmed/id/9808078

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0034380, umls-concept:C0360105
pubmed:issue	3 Suppl B
pubmed:dateCreated	1999-1-15
pubmed:abstractText	Since their introduction, the selective serotonin reuptake inhibitors (SSRIs) have become one of the most widely used classes of medication in psychiatry. Their popularity is based on apparent efficacy over a wide range of disorders and a favorable side-effect profile. However, as with any psychotropic medication, considerable data are required to define where a drug works and where it does not. There is now a wealth of evidence demonstrating that SSRIs may differ in their efficacy profiles in certain depressive symptoms, in different subtypes of depression, with respect to their ability to maintain efficacy over time, on broader outcomes such as quality of life, and in the consistency of the usually effective minimum therapeutic dose across the age spectrum and across indications. Although this review includes data on all SSRIs, it focuses on fluoxetine and sertraline, which in addition to being the most widely used SSRIs are also the most widely studied. The relative quantity and quality of data on these two SSRIs means that it is possible to make relatively firm inferences regarding their differential effects on affective symptoms and quality of life.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8907828
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Uptake Inhibitors
pubmed:status	MEDLINE
pubmed:issn	0269-8811
pubmed:author	pubmed-author:GoldsteinB JBJ, pubmed-author:GoodnickP JPJ
pubmed:issnType	Print
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	S21-54
pubmed:dateRevised	2004-11-17
pubmed:meshHeading	pubmed-meshheading:9808078-Cognition Disorders, pubmed-meshheading:9808078-Humans, pubmed-meshheading:9808078-Mood Disorders, pubmed-meshheading:9808078-Quality of Life, pubmed-meshheading:9808078-Serotonin Uptake Inhibitors
pubmed:year	1998
pubmed:articleTitle	Selective serotonin reuptake inhibitors in affective disorders--II. Efficacy and quality of life.
pubmed:affiliation	Department of Psychiatry and Behavioral Sciences, Health Services Research Center, University of Miami School of Medicine, Florida 33136, USA.
pubmed:publicationType	Journal Article, Review