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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
|
pubmed:dateCreated |
1978-9-29
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pubmed:abstractText |
Pretreatment of rhesus macaques with nonlethal total-body x-irradiation (400 R) prolonged survival time from an average of 15 hours to 101 hours after intravenous (IV) inoculation of 50 microgram of staphylococcal enterotoxin B (SEB)/kg of body weight. Radiation exposure per se did not produce detectable cardiorenal changes; however, the longer survival after SEB challenge exposure in x-irradiated rhesus macaques was associated with improved cardiorenal functions if compared with that of nonirradiated macaques given the same dose of SEB. Total-body radiation exposure 4 days prior to IV SEB inoculation prevented typical SEB-induced decreases (where measured at 5 hours) in cardiac output, stroke volume, TcH2O, CPAH, Cosm, and urine flow, as well as increases in total peripheral and renal resistance. A theory concerning the significance of radiation-induced leukopenia on modification of SEB-induced cardiorenal functions is postulated.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9645
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1213-7
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:98079-Animals,
pubmed-meshheading:98079-Cardiac Output,
pubmed-meshheading:98079-Enterotoxins,
pubmed-meshheading:98079-Female,
pubmed-meshheading:98079-Haplorhini,
pubmed-meshheading:98079-Heart,
pubmed-meshheading:98079-Kidney,
pubmed-meshheading:98079-Macaca,
pubmed-meshheading:98079-Macaca mulatta,
pubmed-meshheading:98079-Monkey Diseases,
pubmed-meshheading:98079-Regional Blood Flow,
pubmed-meshheading:98079-Staphylococcus,
pubmed-meshheading:98079-Vascular Resistance,
pubmed-meshheading:98079-X-Rays
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pubmed:year |
1978
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pubmed:articleTitle |
Effect of staphylococcal enterotoxin B on cardiorenal functions and survival in X-irradiated rhesus macaques.
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pubmed:publicationType |
Journal Article
|