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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1998-11-30
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pubmed:abstractText |
Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserved signal-transduction cascades. This article looks at the mechanisms of action of five natural products--the immunosuppressants cyclosporin A, FK506 and rapamycin, and the antiproliferative agents wortmannin and geldanamycin. These mechanisms reveal the importance of signal-transduction cascades as targets for therapeutic intervention and the enormous utility of studies of natural-product action in simple model genetic systems.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Androstadienes,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Calcineurin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/HSP90 Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Lactams, Macrocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Quinones,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus,
http://linkedlifedata.com/resource/pubmed/chemical/geldanamycin,
http://linkedlifedata.com/resource/pubmed/chemical/wortmannin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0167-7799
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
427-33
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9807840-Androstadienes,
pubmed-meshheading:9807840-Animals,
pubmed-meshheading:9807840-Apoptosis,
pubmed-meshheading:9807840-Benzoquinones,
pubmed-meshheading:9807840-Calcineurin,
pubmed-meshheading:9807840-Cell Cycle,
pubmed-meshheading:9807840-Cyclosporine,
pubmed-meshheading:9807840-Enzyme Inhibitors,
pubmed-meshheading:9807840-Fungi,
pubmed-meshheading:9807840-HSP90 Heat-Shock Proteins,
pubmed-meshheading:9807840-Humans,
pubmed-meshheading:9807840-Immunosuppressive Agents,
pubmed-meshheading:9807840-Lactams, Macrocyclic,
pubmed-meshheading:9807840-Protein Biosynthesis,
pubmed-meshheading:9807840-Quinones,
pubmed-meshheading:9807840-Signal Transduction,
pubmed-meshheading:9807840-Sirolimus,
pubmed-meshheading:9807840-Tacrolimus
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pubmed:year |
1998
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pubmed:articleTitle |
Signal-transduction cascades as targets for therapeutic intervention by natural products.
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pubmed:affiliation |
Department of Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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