| pubmed-article:9806899 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9806899 | lifeskim:mentions | umls-concept:C1333336 | lld:lifeskim |
| pubmed-article:9806899 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:9806899 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9806899 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9806899 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:9806899 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:9806899 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9806899 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9806899 | lifeskim:mentions | umls-concept:C0301039 | lld:lifeskim |
| pubmed-article:9806899 | pubmed:dateCreated | 1999-1-6 | lld:pubmed |
| pubmed-article:9806899 | pubmed:abstractText | Egr-1 (early-growth response factor-1) is a sequence-specific transcription factor that plays a regulatory role in the expression of many genes important for cell growth, development and the pathogenesis of disease. The transcriptional co-activators CBP (cAMP-response-element-binding-protein-binding protein) and p300 interact with sequence-specific transcription factors as well as components of the basal transcription machinery to facilitate RNA polymerase II recruitment and transcriptional initiation. Here we demonstrate a unique way in which Egr-1 physically and functionally interacts with CBP/p300 to modulate gene transcription. CBP/p300 potentiated Egr-1 mediated expression of 5-lipoxygenase (5-LO) promoter-reporter constructs, and the degree of trans-activation was proportional to the number of Egr-1 consensus binding sites present in wild-type and naturally occurring mutants of the 5-LO promoter. The N- and C-terminal domains of CBP interact with the transcriptional activation domain of Egr-1, as demonstrated by a mammalian two-hybrid assay. Direct protein-protein interactions between CBP/p300 and Egr-1 were demonstrated by glutathione S-transferase fusion-protein binding and co-immunoprecipitation/Western-blot studies. These data suggest that CBP and p300 act as transcriptional co-activators for Egr-1-mediated gene expression and that variations between individuals in such co-activation could serve as a genetic basis for variability in gene expression. | lld:pubmed |
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| pubmed-article:9806899 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9806899 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9806899 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9806899 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9806899 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9806899 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:9806899 | pubmed:author | pubmed-author:WilliamsA JAJ | lld:pubmed |
| pubmed-article:9806899 | pubmed:author | pubmed-author:EMSS | lld:pubmed |
| pubmed-article:9806899 | pubmed:author | pubmed-author:DrazenJ MJM | lld:pubmed |
| pubmed-article:9806899 | pubmed:author | pubmed-author:CollinsTT | lld:pubmed |
| pubmed-article:9806899 | pubmed:author | pubmed-author:WadgaonkarRR | lld:pubmed |
| pubmed-article:9806899 | pubmed:author | pubmed-author:SilvermanE... | lld:pubmed |
| pubmed-article:9806899 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9806899 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9806899 | pubmed:volume | 336 ( Pt 1) | lld:pubmed |
| pubmed-article:9806899 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9806899 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9806899 | pubmed:pagination | 183-9 | lld:pubmed |
| pubmed-article:9806899 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9806899 | pubmed:meshHeading | pubmed-meshheading:9806899-... | lld:pubmed |
| pubmed-article:9806899 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9806899 | pubmed:articleTitle | cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1). | lld:pubmed |
| pubmed-article:9806899 | pubmed:affiliation | Vascular Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:9806899 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9806899 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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