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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-1-29
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pubmed:abstractText |
Sodium nitroprusside (SNP) (10(-9)-10(-6) mol) and carbachol (10(-9)-10(-6) mol) induced dose-dependent vasodilatation in the perfused rabbit isolated ovarian vascular bed. Carbachol, but not SNP-induced vasodilatation was abolished by treatment with CHAPS (4. 7 mg ml-1, 30 s) to remove the endothelium. Carbachol-induced responses were also significantly attenuated by LY 83583 (10(-5) M) and methylene blue (3x10(-5) M). L-NOARG (10(-5) M) reduced carbachol-induced vasodilatation. None of these compounds affected SNP-induced vasodilator responses. Both SNP- and carbachol-induced vasodilatation were attenuated by raising the [K+] in the Krebs' solution to 40 mM. The responses were also reduced by TEA (20 mM) but not by glibenclamide. It was therefore concluded that SNP induced cGMP-independent vasodilator responses in the perfused rabbit ovarian vascular bed. This vasodilator response involved membrane hyperpolarisation since it was lost in high [K+] Krebs' solution. (c) 1998 The Italian Pharmacological Society.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6-anilino-5,8-quinolinedione,
http://linkedlifedata.com/resource/pubmed/chemical/Aminoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Carbachol,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Methylene Blue,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Donors,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1043-6618
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
381-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9806818-Aminoquinolines,
pubmed-meshheading:9806818-Animals,
pubmed-meshheading:9806818-Carbachol,
pubmed-meshheading:9806818-Cyclic GMP,
pubmed-meshheading:9806818-Endothelium, Vascular,
pubmed-meshheading:9806818-Enzyme Inhibitors,
pubmed-meshheading:9806818-Female,
pubmed-meshheading:9806818-Guanylate Cyclase,
pubmed-meshheading:9806818-Methylene Blue,
pubmed-meshheading:9806818-Nitric Oxide,
pubmed-meshheading:9806818-Nitric Oxide Donors,
pubmed-meshheading:9806818-Nitric Oxide Synthase,
pubmed-meshheading:9806818-Nitric Oxide Synthase Type III,
pubmed-meshheading:9806818-Nitroarginine,
pubmed-meshheading:9806818-Nitroprusside,
pubmed-meshheading:9806818-Ovary,
pubmed-meshheading:9806818-Rabbits,
pubmed-meshheading:9806818-Vasodilation
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pubmed:year |
1998
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pubmed:articleTitle |
Sodium nitroprusside-induced cGMP-independent vasodilator responses in the perfused rabbit ovarian vascular bed.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Medicine, Kuwait University, Safat, 13110, Kuwait.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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