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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0035015,
umls-concept:C0039194,
umls-concept:C0205178,
umls-concept:C0205314,
umls-concept:C0450127,
umls-concept:C0599894,
umls-concept:C0679622,
umls-concept:C1179841,
umls-concept:C1420649,
umls-concept:C1548437,
umls-concept:C1708528,
umls-concept:C1882923
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pubmed:issue |
4
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pubmed:dateCreated |
1998-11-18
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pubmed:databankReference |
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pubmed:abstractText |
A novel 75 kDa membrane protein, TIRC7, is described that exhibits a central role in T cell activation in vitro and in vivo. Modulation of TIRC7-mediated signals with specific anti-TIRC7 antibodies in vitro efficiently prevents human T cell proliferation and IL-2 secretion. Moreover, anti-TIRC7 antibodies specifically inhibit type 1 subset specific IFN-gamma expression but spare the type 2 cytokine IL-4. Diminished proliferation but not IFN-gamma secretion is reversible by exogenous rIL-2. An anti-TIRC7 antibody that cross-reacts with the 75 kDa rat homolog exhibits inhibition of rat alloimmune response in vitro and significantly prolongs kidney allograft survival in vivo. Targeting of TIRC7 may provide a novel therapeutic approach for modulation of the immune response.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1074-7613
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pubmed:author |
pubmed-author:BeatsBB,
pubmed-author:BeldenT ATA,
pubmed-author:BlumbergR SRS,
pubmed-author:BulwinG CGC,
pubmed-author:BusconiLL,
pubmed-author:GullansS RSR,
pubmed-author:HeinemannTT,
pubmed-author:KojimaRR,
pubmed-author:MilfordE LEL,
pubmed-author:RandallJJ,
pubmed-author:RobertsonE SES,
pubmed-author:SchüleinRR,
pubmed-author:TulliusS GSG,
pubmed-author:UtkuNN,
pubmed-author:VolkH DHD
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pubmed:issnType |
Print
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pubmed:volume |
9
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
509-18
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9806637-Acute Disease,
pubmed-meshheading:9806637-Amino Acid Sequence,
pubmed-meshheading:9806637-Animals,
pubmed-meshheading:9806637-Antibodies,
pubmed-meshheading:9806637-Base Sequence,
pubmed-meshheading:9806637-DNA, Complementary,
pubmed-meshheading:9806637-DNA Primers,
pubmed-meshheading:9806637-Graft Rejection,
pubmed-meshheading:9806637-Humans,
pubmed-meshheading:9806637-Interleukin-2,
pubmed-meshheading:9806637-Kidney Transplantation,
pubmed-meshheading:9806637-Lymphocyte Activation,
pubmed-meshheading:9806637-Male,
pubmed-meshheading:9806637-Membrane Proteins,
pubmed-meshheading:9806637-Molecular Sequence Data,
pubmed-meshheading:9806637-Molecular Weight,
pubmed-meshheading:9806637-Protein Subunits,
pubmed-meshheading:9806637-RNA, Messenger,
pubmed-meshheading:9806637-Rats,
pubmed-meshheading:9806637-Rats, Inbred Lew,
pubmed-meshheading:9806637-Rats, Inbred WF,
pubmed-meshheading:9806637-Signal Transduction,
pubmed-meshheading:9806637-T-Lymphocytes,
pubmed-meshheading:9806637-Transplantation, Homologous,
pubmed-meshheading:9806637-Vacuolar Proton-Translocating ATPases
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein.
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|
pubmed:affiliation |
Institut für Medizinische Immunologie, Campus Mitte, Humboldt Universität zu Berlin, Germany. nalan.utku@charite.de
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
