Linked Life Data

9806613

Source:http://linkedlifedata.com/resource/pubmed/id/9806613

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Suppl
pubmed:dateCreated
1998-11-20
pubmed:abstractText
Radiation-induced DNA damage can induce death by apoptosis by activation of signal transduction pathways. One such pathway is the sphingomyelin/ceramide signal transduction pathway that is involved in initiation of stress-induced apoptosis in a variety of normal and neoplastic cells. This pathway is under regulation by the protein kinase C (PKC) pathway that constitutes an anti-apoptosis mechanism. DNA damage can also increase ceramide levels by activating the biosynthesis pathway, through the activation of the ceramide synthase enzyme. Both pathways could serve as potential targets for strategies that take advantage of signaling-based apoptosis to enhance cell killing in radiation therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0033-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
150
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S102-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Radiation-induced signal transduction and stress response.
pubmed:affiliation
Memorial Sloan-Kettering Cancer Center, Department of Radiation Oncology, New York, New York 10021, USA.
pubmed:publicationType
Journal Article, Review