Linked Life Data

9805315

Source:http://linkedlifedata.com/resource/pubmed/id/9805315

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-2-5
pubmed:abstractText
The objective of this study was to investigate in vitro abomasal motility in dairy cows diagnosed with displaced abomasum. Longitudinal muscle myenteric plexus preparations originating from the abomasal antrum of control cows, and cows diagnosed with left displaced abomasum (LDA), right displaced abomasum (RDA) or abomasal volvulus (AV) were used. In control preparations electrical field stimulation evoked an immediate cholinergic contractile response exceeding amplitude of basal contractions by 60%. In contrast, contractile activity was significantly inhibited during electrical stimulation in LDA, RDA and AV by 47%, 66% and 45%, respectively. This inhibition was reversed in the presence of L-NAME. The staining intensity of NADPH-positive myenteric neurones was significantly higher in displaced abomasa than in controls. Concentration-response curves indicated that preparations from displaced abomasa showed reduced sensitivity to acetylcholine. This study demonstrated motility disorders in displaced abomasa in vitro. The results suggested that abomasal displacement is associated with malfunctions at the level of the intrinsic nervous system combined with impaired cholinergic muscle responses. There appeared to be a predominance of nitrergic inhibitory mechanisms over excitatory mechanisms. These results might be of significance for diseases associated with gastric hypomotility and emptying disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1350-1925
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
395-401
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
In vitro motility disorders associated with displaced abomasum in dairy cows.
pubmed:affiliation
Medical and Forensic Veterinary Clinic II (Internal Diseases of Ruminants), Justus-Liebig-University, Giessen, Germany.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't