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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-12-29
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pubmed:abstractText |
Previous studies have demonstrated that oxygen consumption and fat oxidation remain elevated in the postexercise period. The purpose of this study was to determine whether malonyl-CoA, an inhibitor of fatty acid oxidation, remains depressed in muscle after exercise. Rats were sprinted for 5 min (40 m/min, 5% grade) or run for 30 min (21 m/min, 15% grade). Red quadriceps malonyl-CoA returned to resting values by 90 min postexercise in the sprinting rats and remained significantly lower at least 90 min postexercise in the 30-min exercise group. AMP-activated protein kinase activity remained significantly elevated (P < 0.05) for 10 min after exercise in both groups. The most rapid rate of glycogen repletion was in the first 30 min postexercise. The respiratory exchange ratio decreased from a nonexercise value of 0.87 +/- 0.01 to an average 0.82 +/- 0.01 during the 90-min period after 30 min of exercise. Thus muscle malonyl-CoA remains depressed and fat oxidation is elevated for relatively prolonged periods after a single bout of exercise. This may allow fat oxidation to contribute more to muscle energy requirements, thus leaving more glucose for replenishment of muscle glycogen.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
8750-7587
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1629-34
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9804562-AMP-Activated Protein Kinases,
pubmed-meshheading:9804562-Acetyl-CoA Carboxylase,
pubmed-meshheading:9804562-Animals,
pubmed-meshheading:9804562-Blood Glucose,
pubmed-meshheading:9804562-Fatty Acids, Nonesterified,
pubmed-meshheading:9804562-Kinetics,
pubmed-meshheading:9804562-Lactic Acid,
pubmed-meshheading:9804562-Male,
pubmed-meshheading:9804562-Malonyl Coenzyme A,
pubmed-meshheading:9804562-Multienzyme Complexes,
pubmed-meshheading:9804562-Muscle, Skeletal,
pubmed-meshheading:9804562-Physical Exertion,
pubmed-meshheading:9804562-Protein Kinases,
pubmed-meshheading:9804562-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9804562-Pulmonary Gas Exchange,
pubmed-meshheading:9804562-Rats,
pubmed-meshheading:9804562-Rats, Sprague-Dawley
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pubmed:year |
1998
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pubmed:articleTitle |
Postexercise recovery of skeletal muscle malonyl-CoA, acetyl-CoA carboxylase, and AMP-activated protein kinase.
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pubmed:affiliation |
Department of Zoology, Brigham Young University, Provo, Utah 84602, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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