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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1999-6-7
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pubmed:abstractText |
THE NMDA receptor antagonist phencyclidine (PCP) has low micromolar affinity for the 5-HT reuptake site, but it is uncertain whether PCP blocks 5-HT reuptake when given systemically to rats in behaviourally stimulating doses. We here report for the first time that systemically administered PCP (5 mg/kg, s.c.) increases extracellular 5-HT levels in the rat medial prefrontal cortex (to 322%) and dorsal hippocampus (to 233%). Increases were found also when citalopram (1 microM) was included in the perfusion medium (to 184 and 180%, respectively). Extracellular 5-HIAA concentrations increased during both conditions, and extracellular GABA decreased in the dorsal hippocampus. It is concluded that systemic PCP treatment elevates extracellular 5-HT levels, probably through mechanisms other than a blockade of 5-HT reuptake.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2985-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9804302-Animals,
pubmed-meshheading:9804302-Brain Chemistry,
pubmed-meshheading:9804302-Citalopram,
pubmed-meshheading:9804302-Dialysis Solutions,
pubmed-meshheading:9804302-Drug Administration Routes,
pubmed-meshheading:9804302-Extracellular Space,
pubmed-meshheading:9804302-Hippocampus,
pubmed-meshheading:9804302-Hydroxyindoleacetic Acid,
pubmed-meshheading:9804302-Injections, Subcutaneous,
pubmed-meshheading:9804302-Male,
pubmed-meshheading:9804302-Microdialysis,
pubmed-meshheading:9804302-Perfusion,
pubmed-meshheading:9804302-Phencyclidine,
pubmed-meshheading:9804302-Prefrontal Cortex,
pubmed-meshheading:9804302-Rats,
pubmed-meshheading:9804302-Rats, Sprague-Dawley,
pubmed-meshheading:9804302-Serotonin,
pubmed-meshheading:9804302-Wakefulness,
pubmed-meshheading:9804302-gamma-Aminobutyric Acid
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pubmed:year |
1998
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pubmed:articleTitle |
Systemic PCP treatment elevates brain extracellular 5-HT: a microdialysis study in awake rats.
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pubmed:affiliation |
Department of Pharmacology, Göteborg University, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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