Linked Life Data

9804189

Source:http://linkedlifedata.com/resource/pubmed/id/9804189

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1998-11-20
pubmed:abstractText
Alpha-CEHC (2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman) is a urinary vitamin E metabolite with a truncated phytyl tail. To test whether natural and synthetic vitamin E are similarly converted to alpha-CEHC, 6 humans consumed 150 mg each RRR-alpha-[5-(C2H3)]- and all rac-alpha-[5,7(C2H3)2]-tocopheryl acetates (d3RRR-alpha- and d6all rac-alpha-tocopheryl acetates, respectively). Plasma was collected at 0, 6, 12 and 24 h; urine (24 h) at 0, 1, 2, 3, 4 and 8 days. Following dosing, plasma was enriched with d3RRR-alpha-tocopherol, while urine was enriched with alpha-CEHC derived from d6all rac-alpha-tocopherol. Thus, synthetic compared with natural vitamin E is preferentially metabolized to alpha-CEHC and excreted.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
437
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Synthetic as compared with natural vitamin E is preferentially excreted as alpha-CEHC in human urine: studies using deuterated alpha-tocopheryl acetates.
pubmed:affiliation
Linus Pauling Institute, Oregon State University, Corvallis 97330, USA. maret.traber@orst.edu
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't