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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1998-11-9
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pubmed:abstractText |
Ras farnesyltransferase inhibitors are known to block the membrane translocalization of oncogenic Ras protein. They inhibit the cytoplasmic mitogen-activated protein kinase signaling cascade related to Ras protein. Thus far, Ras farnesyltransferase inhibitors have been exclusively regarded with the anticancer drugs. The object of this study was to elucidate the role of Ras farnesyltransferase inhibitors on the corneal opacity induced by an inflammatory stimulus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2245-51
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9804132-Administration, Topical,
pubmed-meshheading:9804132-Alkyl and Aryl Transferases,
pubmed-meshheading:9804132-Animals,
pubmed-meshheading:9804132-Cell Count,
pubmed-meshheading:9804132-Corneal Edema,
pubmed-meshheading:9804132-Corneal Neovascularization,
pubmed-meshheading:9804132-Corneal Opacity,
pubmed-meshheading:9804132-Endothelium, Corneal,
pubmed-meshheading:9804132-Enzyme Inhibitors,
pubmed-meshheading:9804132-Epithelium, Corneal,
pubmed-meshheading:9804132-Female,
pubmed-meshheading:9804132-Flow Cytometry,
pubmed-meshheading:9804132-Gliotoxin,
pubmed-meshheading:9804132-Keratitis,
pubmed-meshheading:9804132-Macrophages,
pubmed-meshheading:9804132-Mice,
pubmed-meshheading:9804132-Mice, Inbred BALB C,
pubmed-meshheading:9804132-Ophthalmic Solutions,
pubmed-meshheading:9804132-Polyenes,
pubmed-meshheading:9804132-Polyunsaturated Alkamides
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pubmed:year |
1998
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pubmed:articleTitle |
Inhibition of corneal inflammation by the topical use of Ras farnesyltransferase inhibitors: selective inhibition of macrophage localization.
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pubmed:affiliation |
Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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