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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-1-7
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pubmed:abstractText |
The effect of Kupffer cell depression on concanavalin A (Con A)-induced cytokine mRNA expression in the liver was studied. Gadolinium chloride (GdCl3) is a commonly used Kupffer cell inhibitor. GdCl3 (40 mg/kg, i.p.) was injected into each mouse, and 24 hr later, Con A (0.2 mg/mouse) was administered. Plasma was obtained at 24 hr after Con A treatment for alanine aminotransferase (ALT) measurement. GdCl3 treatment inhibited Con A-induced elevation of ALT. However, it did not inhibit Con A-induced interleukin-2 or tumor necrosis factor-alpha mRNA expression. The present results suggest that Kupffer cells are not responsible for Con A-induced cytokine expression in the liver.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-5198
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
101-3
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9804071-Alanine Transaminase,
pubmed-meshheading:9804071-Animals,
pubmed-meshheading:9804071-Anti-Inflammatory Agents,
pubmed-meshheading:9804071-Concanavalin A,
pubmed-meshheading:9804071-Cytokines,
pubmed-meshheading:9804071-Female,
pubmed-meshheading:9804071-Gadolinium,
pubmed-meshheading:9804071-Gene Expression,
pubmed-meshheading:9804071-Gene Expression Regulation,
pubmed-meshheading:9804071-Interleukin-2,
pubmed-meshheading:9804071-Kupffer Cells,
pubmed-meshheading:9804071-Liver,
pubmed-meshheading:9804071-Mice,
pubmed-meshheading:9804071-Mice, Inbred BALB C,
pubmed-meshheading:9804071-RNA, Messenger,
pubmed-meshheading:9804071-Tumor Necrosis Factor-alpha
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pubmed:year |
1998
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pubmed:articleTitle |
Effect of gadolinium chloride treatment on concanavalin A-induced cytokine mRNA expression in mouse liver.
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pubmed:affiliation |
Research Laboratories, Nippon Chemiphar Co., Ltd., Misato, Saitama, Japan.
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pubmed:publicationType |
Journal Article
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