Linked Life Data

9802840

Source:http://linkedlifedata.com/resource/pubmed/id/9802840

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-3-1
pubmed:abstractText
Calmodulin (CaM) presence and concentration was determined (RIA) in the rat hypothalamus (2, 6, 12, 24 h and 90 days after birth) in vehicle-treated animal (controls), in testosterone propionate (TP)-treated females (30 microg/rat subcutaneously 1 h after birth) and in tamoxifen-treated males (200 microg/rat subcutaneously 1 h after birth). CaM concentration, either as total content/hypothalamus or as concentration per mg ww, was significantly higher in both male and female adult rats than in newborn subjects. CaM concentration/mg protein increased with age, being two times higher in adult males and greater than three times higher in adult females than in their respective newborns. Two, 12, and 24 h after birth CaM concentration was significantly lower in control females than in control males. This relation was reversed in adults in which CaM concentration was higher in females. The application of TP to the females and tamoxifen to the males, induced a significant decrease in CaM/mg protein, both in the newborn (2 and 6 h) and in the adult animals. In adults, treated females had CaM concentrations similar to those found in control males. Our data suggest: first, a lasting effect of newborn hormonal treatment upon the CaM concentration in rat hypothalamus; second, that CaM is preferentially synthesized in the adult female hypothalamus, indicating an important role of this protein in female reproductive function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
445-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Changes in hypothalamic calmodulin concentration induced by perinatal hormone manipulation in the rat.
pubmed:affiliation
División de Investigación Biomédica, Unidad de Investigación Médica en Biología de la Reproducción, Hospital de Gineco-Obstetrica Luis Castelazo Ayala, IMSS México DF, México.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't