Linked Life Data

9802434

Source:http://linkedlifedata.com/resource/pubmed/id/9802434

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-1-19
pubmed:abstractText
Neuropeptide Y (NPY) is a potent endogenous appetite transducer but the NPY receptor subtype mediating the induction of appetite is unknown. Evaluation of hypothalamic NPY Y1 and Y5 receptor mRNA by RNase protection assay showed that appetite evoked either by fasting or food-restriction increased expression of Y1 mRNA. Suppression of appetite by the cytokine, ciliary neurotropic factor, blocked this increase in Y1 gene expression. In contrast Y5 mRNA levels were unchanged by these treatments. These findings suggest that NPY-induced stimulation of appetite requires signal transmission though Y1 receptor subtype in the hypothalamus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0167-0115
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
75-76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Increased appetite augments hypothalamic NPY Y1 receptor gene expression: effects of anorexigenic ciliary neurotropic factor.
pubmed:affiliation
Department of Neuroscience, University of Florida College of Medicine, Gainesville 32610-0244, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.