Linked Life Data

9802406

Source:http://linkedlifedata.com/resource/pubmed/id/9802406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-1-19
pubmed:abstractText
While the presence of neuropeptide Y (NPY) in the adrenal cortex is well established, little is known about its regulation. In the present study the involvement of the pituitary gland in the regulation of rat adrenal NPY content was investigated. Rats were subjected to one of the following treatments: hypophysectomy, sham operation, ACTH, the synthetic glucocorticoid, dexamethasone, dexamethasone plus ACTH, or saline control. The immunoreactive NPY (irNPY) content of both capsule/zona glomerulosa and inner zone/medulla fractions were estimated by radioimmunoassay. Treatment with ACTH caused a significant decrease in both the capsular/zona glomerulosa and the inner zone/medulla irNPY content compared with controls, while hypophysectomy resulted in a significant increase in adrenal irNPY. Dexamethasone treatment caused a significant increase in capsular irNPY, which was reversed by simultaneous administration of ACTH. In the medulla, however, dexamethasone treatment significantly decreased irNPY content. These results suggest that there is differential regulation of adrenal irNPY content, with irNPY in the zona glomerulosa regulated directly by ACTH, while the irNPY content of the inner zones/medulla is regulated by glucocorticoids.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0167-0115
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
75-76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-80
pubmed:dateRevised
2010-8-25
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Regulation of rat adrenal neuropeptide Y (NPY) content: effects of ACTH, dexamethasone and hypophysectomy.
pubmed:affiliation
Department of Biochemistry, St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK. j.hinson@qmw.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't