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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9137
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pubmed:dateCreated |
1998-11-17
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pubmed:abstractText |
Estimates of an 80-90% risk of breast cancer for carriers of germline mutations in the BRCA1 and BRCA2 genes are based on studies of families at high risk of breast cancer. Risk estimates for a population are possible if the mutation status of a representative sample of that population can be assessed. In Iceland, one common founder BRCA2 mutation occurs in 0.6% of the population. Iceland has a population-based cancer registry and a large collection of pedigrees, and estimation of cancer risk in mutation carriers is therefore possible.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0140-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
352
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1337-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9802270-Aged,
pubmed-meshheading:9802270-BRCA2 Protein,
pubmed-meshheading:9802270-Breast Neoplasms,
pubmed-meshheading:9802270-Breast Neoplasms, Male,
pubmed-meshheading:9802270-Female,
pubmed-meshheading:9802270-Heterozygote,
pubmed-meshheading:9802270-Humans,
pubmed-meshheading:9802270-Iceland,
pubmed-meshheading:9802270-Male,
pubmed-meshheading:9802270-Middle Aged,
pubmed-meshheading:9802270-Mutation,
pubmed-meshheading:9802270-Neoplasm Proteins,
pubmed-meshheading:9802270-Pedigree,
pubmed-meshheading:9802270-Population Surveillance,
pubmed-meshheading:9802270-Prostatic Neoplasms,
pubmed-meshheading:9802270-Registries,
pubmed-meshheading:9802270-Risk Factors,
pubmed-meshheading:9802270-Transcription Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Population-based study of risk of breast cancer in carriers of BRCA2 mutation.
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pubmed:affiliation |
Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, Reykjavik.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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