Linked Life Data

9801728

Source:http://linkedlifedata.com/resource/pubmed/id/9801728

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-1-5
pubmed:abstractText
Osteoblasts and osteoclasts are derived from progenitors originating in the bone marrow, and the process of bone remodeling is controlled by growth factors and cytokines which regulate the birth and death of these cells. An overproduction of osteoclasts relative to the need for remodeling, and an undersupply of osteoblasts relative to the need for cavity repair, represent the fundamental pathophysiologic changes in postmenopausal and age-related osteopenia, respectively. As in these two forms of the disease, the osteoporosis induced by glucocorticoid excess is also caused by changes in the birth and death of bone cells, and in particular a decrease in osteoblastogenesis in the bone marrow, and an increased rate of osteoblast and osteocyte apoptosis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0394-9532
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
182-90
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Cellular and molecular mechanisms of osteoporosis.
pubmed:affiliation
Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock 72205-7199, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review