|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1998-11-10
|
|
pubmed:abstractText |
To investigate the CYP2C19 polymorphism in Tanzanians because this enzyme shows large interindividual differences in activity and metabolizes several drugs of importance in Africa, especially the antimalarial agent chloroguanide (INN, proguanil).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Ulcer Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/CYP2C19 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Mephenytoin,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Omeprazole
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0009-9236
|
|
pubmed:author |
pubmed-author:AbdiY AYA,
pubmed-author:AltHH,
pubmed-author:BertilssonLL,
pubmed-author:DahlM LML,
pubmed-author:GustafssonL LLL,
pubmed-author:HerrlinKK,
pubmed-author:JandaAA,
pubmed-author:JohanssonII,
pubmed-author:MasseleA YAY,
pubmed-author:TybringGG,
pubmed-author:WennerholmAA
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
64
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
391-401
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9797796-Administration, Oral,
pubmed-meshheading:9797796-Adolescent,
pubmed-meshheading:9797796-Adult,
pubmed-meshheading:9797796-African Continental Ancestry Group,
pubmed-meshheading:9797796-Alleles,
pubmed-meshheading:9797796-Anti-Ulcer Agents,
pubmed-meshheading:9797796-Anticonvulsants,
pubmed-meshheading:9797796-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:9797796-Cytochrome P-450 Enzyme System,
pubmed-meshheading:9797796-DNA Primers,
pubmed-meshheading:9797796-Enzyme Inhibitors,
pubmed-meshheading:9797796-Female,
pubmed-meshheading:9797796-Genotype,
pubmed-meshheading:9797796-Humans,
pubmed-meshheading:9797796-Male,
pubmed-meshheading:9797796-Mephenytoin,
pubmed-meshheading:9797796-Middle Aged,
pubmed-meshheading:9797796-Mixed Function Oxygenases,
pubmed-meshheading:9797796-Mutation,
pubmed-meshheading:9797796-Omeprazole,
pubmed-meshheading:9797796-Phenotype,
pubmed-meshheading:9797796-Polymerase Chain Reaction,
pubmed-meshheading:9797796-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:9797796-Reference Values,
pubmed-meshheading:9797796-Tanzania
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype.
|
|
pubmed:affiliation |
Department of Medical Laboratory Sciences and Technology, Karolinska Institute, Huddinge University Hospital, Sweden.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
