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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-11-30
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pubmed:abstractText |
Amidated gastrins are acid secretagogues and growth factors. Their precursor, progastrin, is a growth factor but not a secretagogue. Cleavage of progastrin at Arg94/95 determines the expression of these two alternative patterns of biological activity. We examined the hypothesis that cleavage at Arg94/95 is regulated by phosphorylation of the adjacent Ser96 residue.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1154-62
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9797370-Amino Acid Sequence,
pubmed-meshheading:9797370-Animals,
pubmed-meshheading:9797370-Calcium,
pubmed-meshheading:9797370-Casein Kinases,
pubmed-meshheading:9797370-Cricetinae,
pubmed-meshheading:9797370-Gastrins,
pubmed-meshheading:9797370-Insulinoma,
pubmed-meshheading:9797370-Mutation,
pubmed-meshheading:9797370-Peptide Fragments,
pubmed-meshheading:9797370-Phosphorylation,
pubmed-meshheading:9797370-Protein Kinases,
pubmed-meshheading:9797370-Protein Precursors,
pubmed-meshheading:9797370-Rats,
pubmed-meshheading:9797370-Transfection,
pubmed-meshheading:9797370-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
Modulation of the cleavage of the gastrin precursor by prohormone phosphorylation.
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pubmed:affiliation |
Physiological Laboratory, University of Liverpool, Liverpool, England.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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