Linked Life Data

9796633

Source:http://linkedlifedata.com/resource/pubmed/id/9796633

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1998-12-17
pubmed:abstractText
We examined the distribution and long-term reliability of serum measurements of the two main human lignans, enterolactone and enterodiol, and the isoflavonoid phytoestrogens daidzein, genistein, equol, and O-Desmethylangolensin in the New York University Women's Health Study, a prospective cohort study of sex hormones and breast cancer. Serum samples collected at three yearly visits in 30 premenopausal and 30 postmenopausal women who had not been diagnosed with cancer or cardiovascular disease were included in the study. Assays were carried out by ion-exchange chromatography and capillary gas chromatography-mass spectrometry. Levels of isoflavonoid phytoestrogens were low, often at or below the sensitivity level of the assay. The reliability coefficients for these compounds were also low (< or =0.30). The median levels of enterodiol and enterolactone were 1.52 nmol/liter and 20.2 nmol/liter, respectively, and were comparable with the levels observed in omnivorous Finnish women living in the Helsinki area. A substantial number of women, though, had fairly high levels: for instance, 15% of the assays showed levels of enterolactone greater than the mean level observed in vegetarian Finnish women, i.e., 89.1 nmol/liter (H. Adlercreutz et al., Cancer Detec. Prev., 18: 259-271, 1994). The reliability coefficient of a single measurement of enterolactone was moderately high (0.55), suggesting that serum measurements of this compound could be a useful tool in prospective epidemiological studies with access to repeated blood or serum specimens. For instance, the reliability coefficient of the average of three measurements of enterolactone would be 0.79, a level considered acceptable in light of the other sources of error that are present in epidemiological studies (W. Willett, Stat. Med., 8: 1031-1040, 1989).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
885-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:9796633-4-Butyrolactone, pubmed-meshheading:9796633-Adult, pubmed-meshheading:9796633-Age Factors, pubmed-meshheading:9796633-Aged, pubmed-meshheading:9796633-Bias (Epidemiology), pubmed-meshheading:9796633-Breast Neoplasms, pubmed-meshheading:9796633-Chromans, pubmed-meshheading:9796633-Equol, pubmed-meshheading:9796633-Feasibility Studies, pubmed-meshheading:9796633-Female, pubmed-meshheading:9796633-Genistein, pubmed-meshheading:9796633-Humans, pubmed-meshheading:9796633-Isoflavones, pubmed-meshheading:9796633-Lignans, pubmed-meshheading:9796633-Middle Aged, pubmed-meshheading:9796633-New York City, pubmed-meshheading:9796633-Pilot Projects, pubmed-meshheading:9796633-Postmenopause, pubmed-meshheading:9796633-Premenopause, pubmed-meshheading:9796633-Reference Values, pubmed-meshheading:9796633-Reproducibility of Results, pubmed-meshheading:9796633-Sensitivity and Specificity, pubmed-meshheading:9796633-Time Factors
pubmed:year
1998
pubmed:articleTitle
Reliability of serum measurements of lignans and isoflavonoid phytoestrogens over a two-year period.
pubmed:affiliation
Nelson Institute of Environmental Medicine, Kaplan Comprehensive Cancer Center, New York University Medical Center, New York 10010-2598, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't