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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-12-24
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pubmed:databankReference |
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pubmed:abstractText |
To identify the proteins which may modulate the functions of peroxisome proliferator-activated receptor (PPAR), a rat liver cDNA library was screened by a yeast two-hybrid system, using the mouse PPARalpha as a bait. A protein named nuclear receptor binding factor-1 (NRBF-1) was identified, which interacts not only with PPARalpha, but also with various nuclear hormone receptors in the presence of the respective ligands. Both the hinge and ligand-binding domains of PPARalpha are required for the interaction. NRBF-1 seems to be translocated to the nucleus by a piggyback mechanism, together with PPARalpha. NRBF-1 has a significant homology to the yeast protein MRF1, a putative transcription factor regulating the expression of mitochondrial respiratory proteins. NRBF-1 might be another type of nuclear receptor co-operator.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
221
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
225-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9795230-Amino Acid Sequence,
pubmed-meshheading:9795230-Animals,
pubmed-meshheading:9795230-Base Sequence,
pubmed-meshheading:9795230-Binding Sites,
pubmed-meshheading:9795230-Biological Transport,
pubmed-meshheading:9795230-Carrier Proteins,
pubmed-meshheading:9795230-Cell Nucleus,
pubmed-meshheading:9795230-Cloning, Molecular,
pubmed-meshheading:9795230-DNA, Complementary,
pubmed-meshheading:9795230-DNA-Binding Proteins,
pubmed-meshheading:9795230-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:9795230-Molecular Sequence Data,
pubmed-meshheading:9795230-Rats,
pubmed-meshheading:9795230-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:9795230-Sequence Alignment,
pubmed-meshheading:9795230-Sequence Analysis, DNA,
pubmed-meshheading:9795230-Sequence Homology, Amino Acid,
pubmed-meshheading:9795230-Transcription Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors.
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pubmed:affiliation |
Department of Life Science, Himeji Institute of Technology, Kamigori, Hyogo 678-1297, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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