| pubmed-article:9795212 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9795212 | lifeskim:mentions | umls-concept:C0026549 | lld:lifeskim |
| pubmed-article:9795212 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9795212 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9795212 | lifeskim:mentions | umls-concept:C1268930 | lld:lifeskim |
| pubmed-article:9795212 | lifeskim:mentions | umls-concept:C0066908 | lld:lifeskim |
| pubmed-article:9795212 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:9795212 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9795212 | pubmed:dateCreated | 1999-6-10 | lld:pubmed |
| pubmed-article:9795212 | pubmed:abstractText | The role of the mu-opioid receptor in immune function was investigated using mu-opioid receptor knockout mice (MOR-KO). Morphine modulation of several immune functions, including macrophage phagocytosis and macrophage secretion of TNF-alpha, was not observed in the MOR-KO animals, suggesting that these functions are mediated by the classical mu-opioid receptor. In contrast, morphine reduction of splenic and thymic cell number and mitogen-induced proliferation were unaffected in MOR-KO mice, as was morphine inhibition of IL-1 and IL-6 secretion by macrophages. These latter results are consistent with morphine action on a naloxone insensitive morphine receptor, a conclusion supported by previous studies characterizing a nonopioid morphine binding site on immune cells. Alternatively, morphine may act either directly or indirectly on these cells, by a mechanism mediated by either delta or kappa opioid receptors. | lld:pubmed |
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| pubmed-article:9795212 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9795212 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9795212 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9795212 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9795212 | pubmed:issn | 0169-328X | lld:pubmed |
| pubmed-article:9795212 | pubmed:author | pubmed-author:LohH HHH | lld:pubmed |
| pubmed-article:9795212 | pubmed:author | pubmed-author:RodHH | lld:pubmed |
| pubmed-article:9795212 | pubmed:author | pubmed-author:BarkeR ARA | lld:pubmed |
| pubmed-article:9795212 | pubmed:copyrightInfo | Copyright 1998 Elsevier Science B.V. | lld:pubmed |
| pubmed-article:9795212 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9795212 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:9795212 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:9795212 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9795212 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9795212 | pubmed:pagination | 190-4 | lld:pubmed |
| pubmed-article:9795212 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9795212 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9795212 | pubmed:articleTitle | MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions. | lld:pubmed |
| pubmed-article:9795212 | pubmed:affiliation | Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. royxx002@gold.tc.umn.edu | lld:pubmed |
| pubmed-article:9795212 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9795212 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9795212 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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