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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1999-6-10
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pubmed:abstractText |
The role of the mu-opioid receptor in immune function was investigated using mu-opioid receptor knockout mice (MOR-KO). Morphine modulation of several immune functions, including macrophage phagocytosis and macrophage secretion of TNF-alpha, was not observed in the MOR-KO animals, suggesting that these functions are mediated by the classical mu-opioid receptor. In contrast, morphine reduction of splenic and thymic cell number and mitogen-induced proliferation were unaffected in MOR-KO mice, as was morphine inhibition of IL-1 and IL-6 secretion by macrophages. These latter results are consistent with morphine action on a naloxone insensitive morphine receptor, a conclusion supported by previous studies characterizing a nonopioid morphine binding site on immune cells. Alternatively, morphine may act either directly or indirectly on these cells, by a mechanism mediated by either delta or kappa opioid receptors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dichloro-N-methyl-N-(2-(1-pyrrol...,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Implants,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogens,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Naltrexone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidine,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0169-328X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1998 Elsevier Science B.V.
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
190-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9795212-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benz...,
pubmed-meshheading:9795212-Animals,
pubmed-meshheading:9795212-Binding, Competitive,
pubmed-meshheading:9795212-Disease Models, Animal,
pubmed-meshheading:9795212-Drug Implants,
pubmed-meshheading:9795212-Exons,
pubmed-meshheading:9795212-Gene Targeting,
pubmed-meshheading:9795212-Immune System,
pubmed-meshheading:9795212-Immunosuppression,
pubmed-meshheading:9795212-Interleukin-2,
pubmed-meshheading:9795212-Ligands,
pubmed-meshheading:9795212-Macrophage Activation,
pubmed-meshheading:9795212-Macrophages, Peritoneal,
pubmed-meshheading:9795212-Mice,
pubmed-meshheading:9795212-Mice, Knockout,
pubmed-meshheading:9795212-Mitogens,
pubmed-meshheading:9795212-Morphine,
pubmed-meshheading:9795212-Naltrexone,
pubmed-meshheading:9795212-Organ Size,
pubmed-meshheading:9795212-Phagocytosis,
pubmed-meshheading:9795212-Receptors, Opioid, mu,
pubmed-meshheading:9795212-Spleen,
pubmed-meshheading:9795212-Substance-Related Disorders,
pubmed-meshheading:9795212-Thymidine,
pubmed-meshheading:9795212-Thymus Gland,
pubmed-meshheading:9795212-Tumor Necrosis Factor-alpha
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pubmed:year |
1998
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pubmed:articleTitle |
MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions.
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pubmed:affiliation |
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. royxx002@gold.tc.umn.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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