Linked Life Data

9795040

Source:http://linkedlifedata.com/resource/pubmed/id/9795040

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1998-12-23
pubmed:abstractText
An antitumor (diamine)platinum moiety was introduced to poly(organophosphazene) by using dicarboxylate spacers, glutamate or aspartate. A liver targeting beta-galactosyl group was also bound to 5-carboxyl-1-pentoxy residue of poly(organophosphazene) by carboxy activation with mixed anhydride method. After characterization of these polymeric conjugates by means of multinuclear (1H, 31P) NMR and IR spectroscopies, elemental analysis and gel-permeation chromatography (GPC), their in vitro hydrolytic behavior were measured by monitoring with GPC in sodium acetate buffer solutions. Hydrolytic properties of the conjugates were dependent on pH and temperature. Over 70% of the platinum moiety was released from the conjugates after incubation for 4 days both in acidic and basic buffer solutions whereas the conjugates were stable in the neutral pH solution.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0168-3659
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-70
pubmed:dateRevised
2000-12-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Synthesis and hydrolytic properties of polyphosphazene/(diamine)platinum/saccharide conjugates.
pubmed:affiliation
Inorganic Chemistry Laboratory, Korea Institute of Science and Technology, Seoul 130-650, South Korea.
pubmed:publicationType
Journal Article